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Protein Modelling Research Group - Laboratory of Structural Chemistry and Biology

Description of the RI

Using both classical organic chemistry and modern bacterial expression systems we synthesize polypeptides, foldamers and proteins of various size and biological significance. Structure elucidation and internal dynamics of biomolecules are completed by X-ray and bioNMR spectroscopy, as well as molecular modeling, applied quantum chemistry and bioinformatics.


Activities and Services

The laboratory cooperates with both Hungarian and foreign research teams on subjects ranging from organic chemistry to molecular biology. We run several ELTE-based, joint research projects, even at the national level, such as MedInProt, HunProtExc, or the SynthPlusz Excellence Programs. Recently we are synthesizing amino acids derived from carbohydrates, determining conformational properties of beta amino acids, synthesizing foldamers, expressing Exenatide-4 analogs used to treat type II Diabetes Mellitus, and conducting research for a better understanding Alzheimer’s and other conformational diseases. Furthermore, we work on the structure and dynamics of kRas signaling protein, which plays an important role in tumor diseases. Devoted students, postdocs and researchers interested in modern structural chemistry and biology are always welcome.

Health and Food

TYPE OF THE RI
Single sited

HOST INSTITUTION
Eötvös Lorand University - Department of Chemistry

LOCATION OF THE RI
Budapest

STATUS
Fully operational, 2002

NATIONAL PARTNERS
  • University of Debrecen (DE)
  • University of Szeged (SZTE)
  • Eötvös Lorand Research Network, Research Centre for Natural Sciences (ELKH TTK)
  • Budapest University of Technology and Economics (BME)

INTERNATIONAL COLLABORATION

With RIs
  • H2020 - iNext: Infrastructure for NMR, EM and X-rays for Translational Research
  • Bio-NMR: NMR for structural Biology
  • East NMR

Institutional partners
  • Sanofi
  • Goethe University

PERSON IN CHARGE/CONTACT
Perczel András, PI
perczel.andras@ttk.elte.hu

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